Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)—a potential mechanism for the anti-cancer effects of ibuprofen†
Abstract
Metabolic chiral inversion of 2-arylpropanoic acids (2-APAs; ‘profens’), such as
* Corresponding authors
a
Medicinal Chemistry, Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
E-mail:
M.D.Lloyd@bath.ac.uk
Fax: +44-1225-386114
Tel: +44-1225-386786
Metabolic chiral inversion of 2-arylpropanoic acids (2-APAs; ‘profens’), such as
T. J. Woodman, P. J. Wood, A. S. Thompson, T. J. Hutchings, G. R. Steel, P. Jiao, M. D. Threadgill and M. D. Lloyd, Chem. Commun., 2011, 47, 7332 DOI: 10.1039/C1CC10763A
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