Issue 22, 2011
From the journal:

Chemical Communications

A serendipitous phosphonocarboxylate complex of boron: when vessel becomes reagent†

Katarzyna M. Błażewska,ab   Ralf Haiges,a   Boris A. Kashemirov,a   Frank H. Ebetinocd  and  Charles E. McKenna*a  

* Corresponding authors

a Department of Chemistry, University of Southern California, Los Angeles, USA
E-mail: mckenna@usc.edu
Fax: +1 213 740 0930
Tel: +1 213 740 2698

b Institute of Organic Chemistry, Technical University of Lodz, Zeromskiego St. 116, 90-924 Lodz, Poland
E-mail: kblazew@p.lodz.pl
Fax: +48 42 636 55 30
Tel: +48 42 631 31 46

c Procter & Gamble Pharmaceuticals, Mason, USA
Tel: +1 513 622 3630

d Warner Chilcott, Dundalk, Louth, Ireland
E-mail: frank.ebetino@wcrx.com

Abstract

Under certain conditions, the phosphonocarboxylate analogue (3) of the bisphosphonate drug minodronate (4) in contact with borosilicate glassware reversibly forms an isolable dimer complex of boron, as revealed by the X-ray crystallographic structure of the (R,R/S,S) complex and supported by NMR and HRMS data.

Graphical abstract: A serendipitous phosphonocarboxylate complex of boron: when vessel becomes reagent

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Article information

DOI
https://doi.org/10.1039/C1CC10876J
Article type
Communication
Submitted
15 Feb 2011
Accepted
31 Mar 2011
First published
09 May 2011

Chem. Commun., 2011,47, 6395-6397

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A serendipitous phosphonocarboxylate complex of boron: when vessel becomes reagent

K. M. Błażewska, R. Haiges, B. A. Kashemirov, F. H. Ebetino and C. E. McKenna, Chem. Commun., 2011, 47, 6395 DOI: 10.1039/C1CC10876J

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