Issue 22, 2011
From the journal:

Chemical Communications

Detection of three-base deletion by exciplex formation with perylene derivatives†

Hiromu Kashida,a   Nobuyo Kondo,a   Koji Sekiguchia  and  Hiroyuki Asanuma*a  

* Corresponding authors

a Graduate School of Engineering, Nagoya University, Furocho, Chikusa-ku, Nagoya 464-8603, Japan
E-mail: asanuma@mol.nagoya-u.ac.jp
Fax: +81-52-789-2528
Tel: +81-52-789-2488

Abstract

Here, we synthesized fluorescent DNA probes labeled with two perylene derivatives for the detection of a three-base deletion mutant. One such probe discriminated the three-base deletion mutant from the wild-type sequence by exciplex emission, and the deletion mutant was identifiable even by the naked eye.

Graphical abstract: Detection of three-base deletion by exciplex formation with perylene derivatives

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Article information

DOI
https://doi.org/10.1039/C1CC11041A
Article type
Communication
Submitted
22 Feb 2011
Accepted
19 Apr 2011
First published
09 May 2011

Chem. Commun., 2011,47, 6404-6406

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Detection of three-base deletion by exciplex formation with perylene derivatives

H. Kashida, N. Kondo, K. Sekiguchi and H. Asanuma, Chem. Commun., 2011, 47, 6404 DOI: 10.1039/C1CC11041A

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