Issue 20, 2011
From the journal:

Chemical Communications

Iron oxide mediated direct C–H arylation/alkylation at α-position of cyclic aliphatic ethers†

Parvinder Pal Singh,a   Satish Gudup,a   Srinivas Ambala,a   Umed Singh,a   Sumit Dadhwal,a   Baldev Singh,a   Sanghapal D. Sawanta  and  Ram A. Vishwakarma*a  

* Corresponding authors

a Medicinal Chemistry Division, Indian Institute of Integrative Medicine (Council of Scientific & Industrial Research), Jammu 180 001, India
E-mail: ram@iiim.res.in
Fax: +91-191-2569333
Tel: +91-191-2569111

Abstract

We report a new and efficient iron oxide catalyzed cross-coupling reaction between organometallic species such as alkyl/arylmagnesium halides or organolithium species and α-hydrogen bearing cyclic aliphatic ethersviaactivation of C(sp3)–H. This is the first example of iron oxide mediated direct C–C bond formation without expensive or toxic ligands.

Graphical abstract: Iron oxide mediated direct C–H arylation/alkylation at α-position of cyclic aliphatic ethers

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Article information

DOI
https://doi.org/10.1039/C1CC11094B
Article type
Communication
Submitted
24 Feb 2011
Accepted
29 Mar 2011
First published
18 Apr 2011

Chem. Commun., 2011,47, 5852-5854

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Iron oxide mediated direct C–H arylation/alkylation at α-position of cyclic aliphatic ethers

P. P. Singh, S. Gudup, S. Ambala, U. Singh, S. Dadhwal, B. Singh, S. D. Sawant and R. A. Vishwakarma, Chem. Commun., 2011, 47, 5852 DOI: 10.1039/C1CC11094B

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