Issue 20, 2011
From the journal:

Chemical Communications

Reaction of arynes with amino acid esters†

Kentaro Okuma,*a   Nahoko Matsunaga,a   Noriyoshi Nagahora,a   Kosei Shiojia  and  Yoshinobu Yokomorib  

* Corresponding authors

a Department of Chemistry, Faculty of Science, Fukuoka University, Jonan-ku, Fukuoka 814-0180, Japan
E-mail: kokuma@fukuoka-u.ac.jp
Fax: +81-92-865-6030
Tel: +81-92-871-6631

b National Defense Academy, Hashirimizu, Yokosuka, Japan
E-mail: yokomori@nda.ac.jp
Fax: +81-46-844-5901
Tel: +81-46-841-3810

Abstract

An efficient route to a variety of 2-phenylindolin-3-ones from amino acid methyl esters has been developed. The reaction of amino acid methyl esters with benzyne prepared from 2-(trimethylsilyl)phenyl triflate and CsF gave 2-phenylindolin-3-ones in moderate to good yields.

Graphical abstract: Reaction of arynes with amino acid esters

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Article information

DOI
https://doi.org/10.1039/C1CC11234A
Article type
Communication
Submitted
02 Mar 2011
Accepted
25 Mar 2011
First published
12 Apr 2011

Chem. Commun., 2011,47, 5822-5824

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Reaction of arynes with amino acid esters

K. Okuma, N. Matsunaga, N. Nagahora, K. Shioji and Y. Yokomori, Chem. Commun., 2011, 47, 5822 DOI: 10.1039/C1CC11234A

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