Issue 23, 2011
From the journal:

Chemical Communications

Electrochemical detection of DNA mutations on a PNA-modified electrode utilizing a single-stranded DNA specific endonuclease†

Sujeong Shin,a   Byoung Yeon Won,a   Cheulhee Jung,a   Sung Chul Shin,a   Dae Yeon Cho,b   Soo Suk Leec  and  Hyun Gyu Park*a  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering (BK21 Program), KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea
E-mail: hgpark@kaist.ac.kr
Fax: +82-42-350-3910
Tel: +82-42-350-3932

b Labgenomics Clinical Research Institute, Labgenomics Co., Ltd., Yong-In 449-795, Republic of Korea

c Bio & Health Lab., Samsung Advanced Institute of Technology, P.O. Box 111, Suwon 440-600, Republic of Korea

Abstract

Utilizing a peptide nucleic acid (PNA)-modified electrode and a single-stranded DNA specific endonuclease, a novel electrochemical method to identify DNA mutations has been developed and represents a totally new strategy for the electrochemical diagnosis of human genetic mutations.

Graphical abstract: Electrochemical detection of DNA mutations on a PNA-modified electrode utilizing a single-stranded DNA specific endonuclease

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Article information

DOI
https://doi.org/10.1039/C1CC11476J
Article type
Communication
Submitted
15 Mar 2011
Accepted
20 Apr 2011
First published
13 May 2011

Chem. Commun., 2011,47, 6611-6613

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Electrochemical detection of DNA mutations on a PNA-modified electrode utilizing a single-stranded DNA specific endonuclease

S. Shin, B. Y. Won, C. Jung, S. C. Shin, D. Y. Cho, S. S. Lee and H. G. Park, Chem. Commun., 2011, 47, 6611 DOI: 10.1039/C1CC11476J

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