Issue 35, 2011
From the journal:

Chemical Communications

A new Os,Rh bimetallic with O2 independent DNA cleavage and DNA photobinding with red therapeutic light excitation†

Jing Wang,a   Samantha L. H. Higgins,a   Brenda S. J. Winkelb  and  Karen J. Brewer*a  

* Corresponding authors

a Department of Chemistry, Virginia Tech., Blacksburg, Virginia 24061-0212, USA
E-mail: kbrewer@vt.edu
Fax: +1 540231-3255
Tel: +1 540231-6579

b Department of Biological Sciences, Virginia Tech., Blacksburg, Virginia 24061-0212, USA

Abstract

Many Ru and Os systems display photoactive 3MLCT states. Systems activated by therapeutic window light in the absence of O2 remain elusive. [(bpy)2Os(dpp)RhCl2(phen)]3+ photobinds and photocleaves DNA under red light in an oxygen independent manner, due to molecular design involving one Os chromophore coupled to a photoactive cis-RhIIICl2 moiety.

Graphical abstract: A new Os,Rh bimetallic with O2 independent DNA cleavage and DNA photobinding with red therapeutic light excitation

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Article information

DOI
https://doi.org/10.1039/C1CC11562F
Article type
Communication
Submitted
17 Mar 2011
Accepted
19 Apr 2011
First published
13 Jun 2011

Chem. Commun., 2011,47, 9786-9788

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A new Os,Rh bimetallic with O2 independent DNA cleavage and DNA photobinding with red therapeutic light excitation

J. Wang, S. L. H. Higgins, B. S. J. Winkel and K. J. Brewer, Chem. Commun., 2011, 47, 9786 DOI: 10.1039/C1CC11562F

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