Issue 23, 2011
From the journal:

Chemical Communications

Gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate: a novel donor substrate in rabbit muscle aldolase-catalyzed aldol reactions†

Michael Fischer,a   Hanspeter Kähliga  and  Walther Schmid*a  

* Corresponding authors

a Department of Organic Chemistry, University of Vienna, Währingerstrasse 38, 1090 Vienna, Austria
E-mail: walther.schmid@univie.ac.at
Fax: +43 14277 9521
Tel: +43 14277 52102

Abstract

An efficient gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate (FHAP) has been developed. As a close analog to dihydroxyacetone phosphate, FHAP was used as a novel donor substrate for rabbit muscle aldolase catalyzed reactions. The different binding affinities of the gem-diol and keto form of FHAP were studied by 19F-NMR.

Graphical abstract: Gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate: a novel donor substrate in rabbit muscle aldolase-catalyzed aldol reactions

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Article information

DOI
https://doi.org/10.1039/C1CC11579K
Article type
Communication
Submitted
18 Mar 2011
Accepted
21 Apr 2011
First published
12 May 2011

Chem. Commun., 2011,47, 6647-6649

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Gram scale synthesis of 3-fluoro-1-hydroxyacetone phosphate: a novel donor substrate in rabbit muscle aldolase-catalyzed aldol reactions

M. Fischer, H. Kählig and W. Schmid, Chem. Commun., 2011, 47, 6647 DOI: 10.1039/C1CC11579K

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