Issue 21, 2011

The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin

Abstract

Cisplatin, cis-[Pt(Cl2(NH3)2], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential metal zinc on the protein.

Graphical abstract: The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin

Supplementary files

Article information

Article type
Communication
Submitted
21 Mar 2011
Accepted
07 Apr 2011
First published
28 Apr 2011

Chem. Commun., 2011,47, 6006-6008

The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin

W. Hu, Q. Luo, K. Wu, X. Li, F. Wang, Y. Chen, X. Ma, J. Wang, J. Liu, S. Xiong and P. J. Sadler, Chem. Commun., 2011, 47, 6006 DOI: 10.1039/C1CC11627D

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