Issue 29, 2011
From the journal:

Chemical Communications

Branched RNA nanostructures for RNA interference†

Yuko Nakashima,ab   Hiroshi Abe,*a   Naoko Abe,a   Kyoko Aikawab  and  Yoshihiro Ito*a  

* Corresponding authors

a Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2-1, Hirosawa, Wako-Shi, Saitama, Japan
E-mail: h-abe@riken.jp, y-ito@riken.jp

b Department of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan

Abstract

Branched RNAs with three- or four-way junctions were designed by assembling single-stranded RNA for RNA interference. Human Dicer transformed branched RNAs into about 20 base pairs of double-stranded RNA, which is a standard siRNA species. Our tetramer design provides a potent silencing effect over a period of 5 days.

Graphical abstract: Branched RNA nanostructures for RNA interference

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Article information

DOI
https://doi.org/10.1039/C1CC11780G
Article type
Communication
Submitted
29 Mar 2011
Accepted
05 May 2011
First published
21 Jun 2011

Chem. Commun., 2011,47, 8367-8369

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Branched RNA nanostructures for RNA interference

Y. Nakashima, H. Abe, N. Abe, K. Aikawa and Y. Ito, Chem. Commun., 2011, 47, 8367 DOI: 10.1039/C1CC11780G

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