Issue 28, 2011

Semi-synthesis of a protease-activatable collagen targeting probe

Abstract

A protease-activatable collagen targeting probe (proCNA35) is synthesized by conjugation of a synthetic collagen fragment to the collagen binding protein CNA35via a protease-cleavable linker. Cleavage of the linker by MMP1 releases the intramolecular inhibition of the collagen binding site and restores its collagen binding capacity.

Graphical abstract: Semi-synthesis of a protease-activatable collagen targeting probe

Supplementary files

Article information

Article type
Communication
Submitted
07 Apr 2011
Accepted
02 Jun 2011
First published
20 Jun 2011

Chem. Commun., 2011,47, 7998-8000

Semi-synthesis of a protease-activatable collagen targeting probe

M. Breurken, E. H. M. Lempens, E. W. Meijer and M. Merkx, Chem. Commun., 2011, 47, 7998 DOI: 10.1039/C1CC11964H

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