A highly active and selective palladium pincer catalyst for the formation of α-aryl ketonesvia cross-coupling

Abstract

Several air and moisture stable Pd(II) pincer complexes were synthesized via oxidative addition of Pd(0) to novel PheBox pincer ligand precursors. Low loadings (1 mol%) of the Pd complex [t-BuPhebox-Me₂]PdBr are capable of efficiently promoting the selective α-monoarylation of a variety of ketones with numerous aryl bromides in only 1 h at 70 °C with 82–99% yields.