Issue 27, 2011
From the journal:

Chemical Communications

A platinum Chugaev carbene complex as a potent anticancer agent†

Georges Alves,abc   Laurent Morel,abc   Malika El-Ghozzi,cd   Daniel Avignant,cd   Bertrand Legeret,ce   Lionel Nauton,ce   Federico Cisnettice  and  Arnaud Gautier*ce  

* Corresponding authors

a CNRS, UMR 6247, GReD Laboratory, 24 Ave des Landais, Aubière, France

b INSERM, U 931, GReD Laboratory, 24 Ave des Landais, Aubière, France

c Clermont Université, Blaise Pascal University, BP 10448, Clermont-Ferrand, France

d CNRS, UMR 6002, LMI Laboratory, 24 Ave des Landais, Aubière, France

e CNRS, UMR 650, SEESIB Laboratory, 24 Ave des Landais, Aubière, France
E-mail: arnaud.gautier@univ-bpclermont.fr
Fax: +33 04 73 40 77 17
Tel: +33 04 73 40 76 46

Abstract

A platinum Chugaev complex was synthesised and fully characterized by multinuclear NMR spectroscopy and X-ray crystallography. This cis bis acyclic diamino carbene complex acts as a cytotoxic compound and behaves as a cisplatin equivalent by interacting with supercoiled DNA and thiols. Stability of the ligand is also discussed.

Graphical abstract: A platinum Chugaev carbene complex as a potent anticancer agent

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CC12228B
Article type
Communication
Submitted
18 Apr 2011
Accepted
19 May 2011
First published
07 Jun 2011

Chem. Commun., 2011,47, 7830-7832

Permissions

Request permissions

A platinum Chugaev carbene complex as a potent anticancer agent

G. Alves, L. Morel, M. El-Ghozzi, D. Avignant, B. Legeret, L. Nauton, F. Cisnetti and A. Gautier, Chem. Commun., 2011, 47, 7830 DOI: 10.1039/C1CC12228B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements