Monofunctionalized pillar[5]arenes: synthesis and supramolecular structure

Abstract

The first synthesis of a monohydroxy pillar[5]arene has been carried out, by controlling the de-O-methylation of per-methylated pillar[5]arene. Using monohydroxy pillar[5]arene as an intermediate, mono-guest-functionalized pillar[5]arene was prepared. It formed a self-inclusion complex in CDCl₃ whereas in acetone-d₆ dethreading of the guest moiety took place.