Designing label-free DNA sequences to achieve controllable turn-off/on fluorescence response for Hg2+ detection

Zece Zhu; Liang Xu; Xiang Zhou; Jingui Qin; Chuluo Yang

doi:10.1039/C1CC12384J

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Designing label-free DNA sequences to achieve controllable turn-off/on fluorescence response for Hg²⁺ detection†

Zece Zhu,^ab Liang Xu,^a Xiang Zhou,^a Jingui Qin^ab and Chuluo Yang*^abc

Author affiliations

* Corresponding authors

^a Department of Chemistry, Wuhan University, Wuhan 430072, China
E-mail: clyang@whu.edu.cn
Fax: (+)86-27-68756757

^b Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, Wuhan 430072, China

^c Key Laboratory of Biomedical Polymers, Ministry of Education, Wuhan 430072, China

Abstract

Controllable turn off/on fluorescent sensors for Hg²⁺ detection were developed by designing different label-free DNA sequences and using the minor groove dye of DAPI. These assays exhibit high sensitivity and selectivity, with the detection limits of 5 nM and 1.5 nM for turn off and turn on sensors, respectively.

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Article information

DOI: https://doi.org/10.1039/C1CC12384J
Article type: Communication
Submitted: 24 Apr 2011
Accepted: 25 May 2011
First published: 14 Jun 2011

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Chem. Commun., 2011,47, 8010-8012

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Designing label-free DNA sequences to achieve controllable turn-off/on fluorescence response for Hg²⁺ detection

Z. Zhu, L. Xu, X. Zhou, J. Qin and C. Yang, Chem. Commun., 2011, 47, 8010 DOI: 10.1039/C1CC12384J

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Chemical Communications