Issue 25, 2011
From the journal:

Chemical Communications

9G DNAChip: microarray based on the multiple interactions of 9 consecutive guanines†

Keum-Soo Song,b   Satish Balasaheb Nimse,a   Joonbae Kim,a   Junghoon Kim,b   Van-Thuan Nguyen,a   Van-Thao Taa  and  Taisun Kim*a  

* Corresponding authors

a Institute for Applied Chemistry and Department of Chemistry, Hallym University, Chuncheon, Korea
E-mail: tskim@hallym.ac.kr
Fax: +82-33-256-3421

b Biometrix Technology, Inc. 202 BioVenture Plaza, Chuncheon, Korea

Abstract

We introduce the phenomenon of molecular recognition to immobilize oligonucleotides on AMCA slides for the production of 9G DNAChips. Facile and efficient method for the immobilization of the oligonucleotides appended with consecutive nine guanine bases is described. The 9G DNAChips shows more than 90% hybridization efficiency at 25 °C in 30 min.

Graphical abstract: 9G DNAChip: microarray based on the multiple interactions of 9 consecutive guanines

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Article information

DOI
https://doi.org/10.1039/C1CC12489G
Article type
Communication
Submitted
28 Apr 2011
Accepted
06 May 2011
First published
27 May 2011
This article is Open Access

Chem. Commun., 2011,47, 7101-7103

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9G DNAChip: microarray based on the multiple interactions of 9 consecutive guanines

K. Song, S. Balasaheb Nimse, J. Kim, J. Kim, V. Nguyen, V. Ta and T. Kim, Chem. Commun., 2011, 47, 7101 DOI: 10.1039/C1CC12489G

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