Issue 33, 2011
From the journal:

Chemical Communications

SNARE derived peptide mimic inducing membrane fusion†

Karsten Meyenberg,a   Antonina S. Lygina,a   Geert van den Bogaart,b   Reinhard Jahnb  and  Ulf Diederichsen*a  

* Corresponding authors

a Institut für Organische und Biomolekulare Chemie, Tammannstr. 2, 37077 G, Germany
E-mail: udieder@gwdg.de
Fax: 49 551-39 22944
Tel: 49 551 39 3221

b Max-Planck-Institut für Biophysikalische Chemie, Am Faßberg 11, 37077 G, Germany

Abstract

SNARE proteins mediate membrane fusion between synaptic vesicles and the plasma membrane. A minimized peptide SNARE model system with reduced complexity was introduced combining the native SNARE transmembrane (TMD) and linker domains with artificial coiled-coil forming peptides. Specific membrane fusion initiated by coiled-coil recognition was shown by lipid and content mixing vesicle assays.

Graphical abstract: SNARE derived peptide mimic inducing membrane fusion

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CC12879E
Article type
Communication
Submitted
16 May 2011
Accepted
28 Jun 2011
First published
20 Jul 2011

Chem. Commun., 2011,47, 9405-9407

Permissions

Request permissions

SNARE derived peptide mimic inducing membrane fusion

K. Meyenberg, A. S. Lygina, G. van den Bogaart, R. Jahn and U. Diederichsen, Chem. Commun., 2011, 47, 9405 DOI: 10.1039/C1CC12879E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements