Issue 32, 2011
From the journal:

Chemical Communications

GeT peptides: a single-domain approach to gene delivery†

Baptiste Lamarre,a   Jascindra Ravia  and  Maxim G. Ryadnov*ab  

* Corresponding authors

a National Physical Laboratory, Teddington, UK
E-mail: max.ryadnov@npl.co.uk
Fax: +44 20 8614 0573
Tel: +44 20 8943 6078

b School of Physics and Astronomy, University of Edinburgh, Edinburgh, UK

Abstract

A generic peptide sequence for gene delivery is described. The sequence penetrates eukaryotic cells and promotes active DNA transport into mammalian cells (EGFP positive) by undergoing differential membrane-induced folding, which renders it both endosomolytic and antibacterial.

Graphical abstract: GeT peptides: a single-domain approach to gene delivery

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Article information

DOI
https://doi.org/10.1039/C1CC13043A
Article type
Communication
Submitted
24 May 2011
Accepted
04 Jul 2011
First published
18 Jul 2011

Chem. Commun., 2011,47, 9045-9047

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GeT peptides: a single-domain approach to gene delivery

B. Lamarre, J. Ravi and M. G. Ryadnov, Chem. Commun., 2011, 47, 9045 DOI: 10.1039/C1CC13043A

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