Issue 31, 2011

Direct amidation of azoles with formamidesvia metal-free C–H activation in the presence of tert-butyl perbenzoate

Abstract

A novel and simple method for the direct amidation of azoles with formamides has been developed. The reaction could occur smoothly in the presence of tert-butyl perbenzoate (TBPB) as an oxidant under metal- and base-free conditions. Direct dehydrogenative cross-coupling of formamides and azoles generated the corresponding products in good yields.

Graphical abstract: Direct amidation of azoles with formamidesvia metal-free C–H activation in the presence of tert-butyl perbenzoate

Supplementary files

Article information

Article type
Communication
Submitted
26 May 2011
Accepted
22 Jun 2011
First published
07 Jul 2011

Chem. Commun., 2011,47, 8946-8948

Direct amidation of azoles with formamidesvia metal-free C–H activation in the presence of tert-butyl perbenzoate

T. He, H. Li, P. Li and L. Wang, Chem. Commun., 2011, 47, 8946 DOI: 10.1039/C1CC13086B

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