Rapid aqueous [18F]-labeling of a bodipy dye for positron emission tomography/fluorescence dual modality imaging

Zibo Li; Tzu-Pin Lin; Shuanglong Liu; Chiun-Wei Huang; Todd W. Hudnall; François P. Gabbaï; Peter S. Conti

doi:10.1039/C1CC13089G

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Rapid aqueous [¹⁸F]-labeling of a bodipy dye for positron emission tomography/fluorescence dual modality imaging†

Zibo Li,‡*^a Tzu-Pin Lin,§^b Shuanglong Liu,§^a Chiun-Wei Huang,^a Todd W. Hudnall,^b François P. Gabbaï ‡*^b and Peter S. Conti^a

Author affiliations

* Corresponding authors

^a Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles 90033, USA
E-mail: ziboli@usc.edu

^b Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA
E-mail: gabbai@mail.chem.tamu.edu

Abstract

We report the rapid nucleophilic [¹⁸F]-radiolabeling of a bodipy dye in aqueous solutions. This radiolabeled dye, whose biodistribution and clearance has been studied in mice, is stable in vivo and can be used as a positron emission tomography/fluorescence dual modality imaging agent.

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Article information

DOI: https://doi.org/10.1039/C1CC13089G
Article type: Communication
Submitted: 26 May 2011
Accepted: 02 Jul 2011
First published: 21 Jul 2011

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Chem. Commun., 2011,47, 9324-9326

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Rapid aqueous [¹⁸F]-labeling of a bodipy dye for positron emission tomography/fluorescence dual modality imaging

Z. Li, T. Lin, S. Liu, C. Huang, T. W. Hudnall, F. P. Gabbaï and P. S. Conti, Chem. Commun., 2011, 47, 9324 DOI: 10.1039/C1CC13089G

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Chemical Communications