Precise engineering and visualization of signs and magnitudes of DNA writhe on the basis of PNA invasion

Dawei Li; Zhaoqi Yang; Yi Long; Guanjia Zhao; Bei Lv; Shuhui Hiew; Magdeline Tao Tao Ng; Juanjuan Guo; HongKee Tan; Hao Zhang; Weixing Yuan; Haibin Su; Tianhu Li

doi:10.1039/C1CC13158C

Precise engineering and visualization of signs and magnitudes of DNA writhe on the basis of PNA invasion†

Dawei Li,^a Zhaoqi Yang,^a Yi Long,^a Guanjia Zhao,^a Bei Lv,^a Shuhui Hiew,^a Magdeline Tao Tao Ng,^a Juanjuan Guo,^a HongKee Tan,^a Hao Zhang,^a Weixing Yuan,^a Haibin Su^a and Tianhu Li*^a

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^a RecDivision of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore
E-mail: thli@ntu.edu.sg
Fax: +65 6791-1961
Tel: +65 6513-7364

Abstract

It is demonstrated that the right and left handedness of DNA supercoils can be engineered precisely and readily at the molecular level in vitro through utilization of the invading property of peptide nucleic acid.

Chemical Communications

Precise engineering and visualization of signs and magnitudes of DNA writhe on the basis of PNA invasion†

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Precise engineering and visualization of signs and magnitudes of DNA writhe on the basis of PNA invasion

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