Issue 37, 2011
From the journal:

Chemical Communications

Imidazole-modified porphyrin as a pH-responsive sensitizer for cancer photodynamic therapy†

Xianchun Zhu,a   Wentong Lu,a   Yazhou Zhang,a   Aisha Reed,a   Brandon Newton,a   Zhen Fan,a   Hongtao Yu,a   Paresh C. Raya  and  Ruomei Gao*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, Jackson State University, Jackson MS 39211, USA
E-mail: ruomei.gao@jsums.edu
Fax: +1 601 979 3674
Tel: +1 601 979 3719

Abstract

5,10,15,20-Tetrakis(N-(2-(1H-imidazol-4-yl)ethyl)benzamide)porphyrin produced twice as many singlet oxygen (1O2) molecules at pH 5.0 (quantum yield 0.53 ± 0.01) than at pH 7.4, whereas the 1O2 quenching rate was reduced by a factor of 2.5 for a pH change from 7.4 to 5.0.

Graphical abstract: Imidazole-modified porphyrin as a pH-responsive sensitizer for cancer photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C1CC13328D
Article type
Communication
Submitted
04 Jun 2011
Accepted
08 Aug 2011
First published
19 Aug 2011

Chem. Commun., 2011,47, 10311-10313

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Imidazole-modified porphyrin as a pH-responsive sensitizer for cancer photodynamic therapy

X. Zhu, W. Lu, Y. Zhang, A. Reed, B. Newton, Z. Fan, H. Yu, P. C. Ray and R. Gao, Chem. Commun., 2011, 47, 10311 DOI: 10.1039/C1CC13328D

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