Issue 35, 2011

2-Lithiated-2-phenyloxetane: a new attractive synthon for the preparation of oxetane derivatives

Abstract

A valuable and direct method to access 2-substituted-2-phenyloxetanes by electrophilic quenching of the corresponding 2-lithiated derivative has, for the first time, been described. 2-Lithiated-2-phenyloxetane was found to be configurationally unstable. Evidence is presented to show that electron-transfer processes are also operative in the coupling reactions with electrophiles.

Graphical abstract: 2-Lithiated-2-phenyloxetane: a new attractive synthon for the preparation of oxetane derivatives

Supplementary files

Article information

Article type
Communication
Submitted
20 Jun 2011
Accepted
14 Jul 2011
First published
04 Aug 2011

Chem. Commun., 2011,47, 9918-9920

2-Lithiated-2-phenyloxetane: a new attractive synthon for the preparation of oxetane derivatives

D. I. Coppi, A. Salomone, F. M. Perna and V. Capriati, Chem. Commun., 2011, 47, 9918 DOI: 10.1039/C1CC13670D

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