Issue 39, 2011
From the journal:

Chemical Communications

DNA reorientation on Au nanoparticles: label-free detection of hybridization by surface enhanced Raman spectroscopy†

Evanthia Papadopouloua  and  Steven E. J. Bell*a  

* Corresponding authors

a Innovative Molecular Materials Group, School of Chemistry and Chemical Engineering, Queen's University, Belfast, UK
E-mail: s.bell@qub.ac.uk
Fax: +44 (0)2890 976524
Tel: +44 (0)2890 974470

Abstract

DNA sequences attached to Au nanoparticlesviathiol linkers stand up from the surface, giving preferential enhancement of the adenine ring breathing SERS band. Non-specific binding via the nucleobases reorients the DNA, reducing this effect. This change in intensity on reorientation was utilised for label-free detection of hybridization of a molecular beacon.

Graphical abstract: DNA reorientation on Au nanoparticles: label-free detection of hybridization by surface enhanced Raman spectroscopy

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Article information

DOI
https://doi.org/10.1039/C1CC13705K
Article type
Communication
Submitted
21 Jun 2011
Accepted
25 Aug 2011
First published
12 Sep 2011

Chem. Commun., 2011,47, 10966-10968

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DNA reorientation on Au nanoparticles: label-free detection of hybridization by surface enhanced Raman spectroscopy

E. Papadopoulou and S. E. J. Bell, Chem. Commun., 2011, 47, 10966 DOI: 10.1039/C1CC13705K

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