Issue 34, 2011
From the journal:

Chemical Communications

Unsymmetrical β-cyclodextrin-conjugated silicon(iv) phthalocyanines as highly potent photosensitisers for photodynamic therapy†

Janet T. F. Lau,a   Pui-Chi Lo,a   Yee-Man Tsang,b   Wing-Ping Fongb  and  Dennis K. P. Ng*a  

* Corresponding authors

a Department of Chemistry, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong, China
E-mail: dkpn@cuhk.edu.hk
Fax: +852 2603 5057

b School of Life Sciences, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong, China

Abstract

A series of unsymmetrical silicon(IV) phthalocyanines with a permethylated β-cyclodextrin unit and a sugar or a diamino moiety as the axial substituents have been prepared. These compounds are highly photocytotoxic with IC50 values as low as 21 nM, which is ca. sevenfold lower than those of the symmetrical bis(cyclodextrin) analogue.

Graphical abstract: Unsymmetrical β-cyclodextrin-conjugated silicon(iv) phthalocyanines as highly potent photosensitisers for photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C1CC13783B
Article type
Communication
Submitted
24 Jun 2011
Accepted
07 Jul 2011
First published
29 Jul 2011

Chem. Commun., 2011,47, 9657-9659

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Unsymmetrical β-cyclodextrin-conjugated silicon(IV) phthalocyanines as highly potent photosensitisers for photodynamic therapy

J. T. F. Lau, P. Lo, Y. Tsang, W. Fong and D. K. P. Ng, Chem. Commun., 2011, 47, 9657 DOI: 10.1039/C1CC13783B

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