Issue 38, 2011
From the journal:

Chemical Communications

A novel magnetic mesoporous silica packed S-shaped microfluidic reactor for online proteolysis of low-MW proteome†

Qianhao Min,a   Xiaoxia Zhang,a   Ren'an Wu,b   Hanfa Zoub  and  Jun-Jie Zhu*a  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P.R. China
E-mail: jjzhu@nju.edu.cn
Fax: (+86)-25-83597204

b CAS Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Dalian 116023, P. R. China

Abstract

Magnetic mesoporous silica with a magnetic cover and mesoporous core was synthesized, filled with trypsin and located in an S-shaped microfluidic reactor. High-molecular weight (MW) proteins were split to waste by fractionation, whilst low-MW proteins were retained on the chip to be digested.

Graphical abstract: A novel magnetic mesoporous silica packed S-shaped microfluidic reactor for online proteolysis of low-MW proteome

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Article information

DOI
https://doi.org/10.1039/C1CC13969J
Article type
Communication
Submitted
03 Jul 2011
Accepted
01 Aug 2011
First published
24 Aug 2011

Chem. Commun., 2011,47, 10725-10727

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A novel magnetic mesoporous silica packed S-shaped microfluidic reactor for online proteolysis of low-MW proteome

Q. Min, X. Zhang, R. Wu, H. Zou and J. Zhu, Chem. Commun., 2011, 47, 10725 DOI: 10.1039/C1CC13969J

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