Sultone opening with [18F]fluoride: an efficient 18F-labelling strategy for PET imaging

Abstract

Sultones were subject to ring opening by nucleophilic attack with [¹⁸F]fluoride to afford easily purified ¹⁸F-labelled hydrophilic sulfonated products in high yields. A two-step sequence including radiofluorination and coupling to lysine was then developed from a bis-sultone precursor as a model approach for the labelling of biopolymers.