Issue 40, 2011
From the journal:

Chemical Communications

Shedding light by cancer redox—human NAD(P)H:quinone oxidoreductase 1 activation of a cloaked fluorescent dye†

William C. Silvers,a   Alex S. Paynea  and  Robin L. McCarley*a  

* Corresponding authors

a Department of Chemistry, Louisiana State University, Baton Rouge, USA
E-mail: TUNNEL@LSU.EDU
Fax: +1 225-578-3458
Tel: +1 225-578-3239

Abstract

A new quinone propionic acid-cloaked rhodamine fluorophore has its fluorescence revealed (de-cloaked) upon activation by human NAD(P)H:quinone oxidoreductase 1 (hNQO1), an upregulated enzyme in cancer cells and tumors.

Graphical abstract: Shedding light by cancer redox—human NAD(P)H:quinone oxidoreductase 1 activation of a cloaked fluorescent dye

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CC14578A
Article type
Communication
Submitted
26 Jul 2011
Accepted
01 Sep 2011
First published
19 Sep 2011

Chem. Commun., 2011,47, 11264-11266

Permissions

Request permissions

Shedding light by cancer redox—human NAD(P)H:quinone oxidoreductase 1 activation of a cloaked fluorescent dye

W. C. Silvers, A. S. Payne and R. L. McCarley, Chem. Commun., 2011, 47, 11264 DOI: 10.1039/C1CC14578A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements