Issue 47, 2011
From the journal:

Chemical Communications

Continuous in situ generation and reaction of phosgene in a microflow system†

Shinichiro Fuse,a   Nobutake Tanabea  and  Takashi Takahashi*a  

* Corresponding authors

a Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1, Ookayama, Meguro-ku, Tokyo 152-8552, Japan
E-mail: ttak@apc.titech.ac.jp
Fax: +81-3-5734-2884
Tel: +81-3-5734-2120

Abstract

Continuous in situ generation of phosgene and its use in acid chloride formation in a microflow system were demonstrated. The acid chloride was subsequently coupled with an amine in high yield without severe epimerization.

Graphical abstract: Continuous in situ generation and reaction of phosgene in a microflow system

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Article information

DOI
https://doi.org/10.1039/C1CC15662D
Article type
Communication
Submitted
13 Sep 2011
Accepted
14 Oct 2011
First published
31 Oct 2011

Chem. Commun., 2011,47, 12661-12663

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Continuous in situ generation and reaction of phosgene in a microflow system

S. Fuse, N. Tanabe and T. Takahashi, Chem. Commun., 2011, 47, 12661 DOI: 10.1039/C1CC15662D

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