Issue 48, 2011
From the journal:

Chemical Communications

Synthesis of isoindolinones viapalladium-catalyzed C–H activation of N-methoxybenzamides†

Dan-Dan Li,a   Ting-Ting Yuana  and  Guan-Wu Wang*a  

* Corresponding authors

a Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry, Joint Laboratory of Green Synthetic Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China
E-mail: gwang@ustc.edu.cn
Fax: +86 551 3607864
Tel: +86 551 3607864

Abstract

The synthesis of isoindolinones from N-methoxybenzamides and alkenes has been achieved by Pd-catalyzed ortho sp2 C–H activation and intramolecular oxidative amidation, which involve the cleavage of four bonds and formation of two bonds.

Graphical abstract: Synthesis of isoindolinones viapalladium-catalyzed C–H activation of N-methoxybenzamides

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Article information

DOI
https://doi.org/10.1039/C1CC15897J
Article type
Communication
Submitted
22 Sep 2011
Accepted
20 Oct 2011
First published
03 Nov 2011

Chem. Commun., 2011,47, 12789-12791

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Synthesis of isoindolinones viapalladium-catalyzed C–H activation of N-methoxybenzamides

D. Li, T. Yuan and G. Wang, Chem. Commun., 2011, 47, 12789 DOI: 10.1039/C1CC15897J

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