A turn-on chemosensor for Hg2+ in aqueous media and its application in “MCT” imaging in living cells

Pinxian Xi; Liang Huang; Guoqiang Xie; Fengjuan Chen; Zhihong Xu; Decheng Bai; Zhengzhi Zeng

doi:10.1039/C1DT10573F

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A turn-on chemosensor for Hg²⁺ in aqueous media and its application in “MCT” imaging in living cells†

Pinxian Xi,^a Liang Huang,^a Guoqiang Xie,^a Fengjuan Chen,^a Zhihong Xu,^b Decheng Bai^c and Zhengzhi Zeng*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China
E-mail: zengzhzh@lzu.edu.cn; zengzhzh@yahoo.com.cn
Fax: +86 931 8912582
Tel: +86 931 8912596

^b College of Chemistry and Chemical Engineering, Xuchang University, Xuchang 461000, P. R. China

^c School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, P. R. China

Abstract

A turn-on chemosensor L1, which exhibits high selectivity and sensitivity toward Hg²⁺ over other common metal ions in aqueous media under a physiological pH window via a 1 : 1 binding mode, had been synthesized and characterized. L1 provides good fluorescent imaging of Hg²⁺ in living cells. Particularly, we adopted the “micro computed tomography (MCT)” technology, successfully demonstrating the method of Hg²⁺ sensing by L1 in cell lines, also the cell permeability of L1 and its imaging position in the cells.

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Article information

DOI: https://doi.org/10.1039/C1DT10573F
Article type: Communication
Submitted: 04 Apr 2011
Accepted: 03 May 2011
First published: 16 May 2011

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Dalton Trans., 2011,40, 6382-6384

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A turn-on chemosensor for Hg²⁺ in aqueous media and its application in “MCT” imaging in living cells

P. Xi, L. Huang, G. Xie, F. Chen, Z. Xu, D. Bai and Z. Zeng, Dalton Trans., 2011, 40, 6382 DOI: 10.1039/C1DT10573F

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Dalton Transactions