Issue 10, 2011
From the journal:

New Journal of Chemistry

Poly(alkylidenamines) dendrimers as scaffolds for the preparation of low-generation ruthenium based metallodendrimers†

João Rodrigues,*a   Manuel G. Jardim,a   João Figueira,a   Marisol Gouveia,a   Helena Tomása  and  Kari Rissanenb  

* Corresponding authors

a CQM-Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus Universitário da Penteada, 9000-390 Funchal, Portugal
E-mail: joaor@uma.pt
Fax: +351-291705149/249
Tel: +351-291705150/5108

b Department of Chemistry, NanoScience Center, University of Jyväskylä, P.O. Box 35, Finland

Abstract

The aim of this article is to highlight the use of nitrile-functionalized poly(alkylidenamines) dendrimers as building blocks for the preparation of low-generation ruthenium based cationic metallodendrimers having in view potential biomedical applications. Air-stable poly(alkylidenamines) nitrile dendrimers, peripherally functionalized with the ruthenium moieties [Ru(η5-C5H5)(PPh3)2]+ or [RuCl(dppe)2]+, have been prepared, characterized and are being studied for their anticancer activity. The followed strategy is based on the biological advantages associated with low-generation dendrimers, the known activity of ruthenium compounds as anticancer drugs and the stability of these dendrimers at the physiological temperature.

Graphical abstract: Poly(alkylidenamines) dendrimers as scaffolds for the preparation of low-generation ruthenium based metallodendrimers

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Article information

DOI
https://doi.org/10.1039/C1NJ20364A
Article type
Focus
Submitted
24 Apr 2011
Accepted
26 May 2011
First published
06 Jul 2011

New J. Chem., 2011,35, 1938-1943

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Poly(alkylidenamines) dendrimers as scaffolds for the preparation of low-generation ruthenium based metallodendrimers

J. Rodrigues, M. G. Jardim, J. Figueira, M. Gouveia, H. Tomás and K. Rissanen, New J. Chem., 2011, 35, 1938 DOI: 10.1039/C1NJ20364A

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