Issue 5, 2011
From the journal:

Nanoscale

Conjugated polyelectrolyte–cisplatin complex nanoparticles for simultaneous in vivo imaging and drug tracking†

Dan Ding,a   Kai Li,a   Zhenshu Zhu,c   Kan-Yi Pu,a   Yong Hu,b   Xiqun Jiangc  and  Bin Liu*a  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore
E-mail: cheliub@nus.edu.sg
Fax: +65 67791936
Tel: +65 65168049

b National Laboratory of Solid State Microstructure, Department of Material Science and Engineering, Nanjing University, Nanjing, P. R. China

c Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, P. R. China

Abstract

A molecular brush based on conjugated polyelectrolyte (CPE) grafted with dense poly(ethylene glycol) (PEG) chains was successfully complexed with an anticancer agent, cisplatin, to form cisplatin-loaded nanoparticles (CPE–PEG–Pt). The obtained nanoparticles have high far-red/near-infrared fluorescence and are able to release the drug in a continuous and slow manner. These nanoparticles have not only been used to visualize HepG2 cancer cells, but also served as an in vivo fluorescent imaging probe that simultaneously tracks the in vivodrug distribution in nude mice upon intravenous administration.

Graphical abstract: Conjugated polyelectrolyte–cisplatin complex nanoparticles for simultaneous in vivo imaging and drug tracking

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Article information

DOI
https://doi.org/10.1039/C0NR00950D
Article type
Paper
Submitted
06 Dec 2010
Accepted
08 Feb 2011
First published
25 Mar 2011

Nanoscale, 2011,3, 1997-2002

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Conjugated polyelectrolyte–cisplatin complex nanoparticles for simultaneous in vivo imaging and drug tracking

D. Ding, K. Li, Z. Zhu, K. Pu, Y. Hu, X. Jiang and B. Liu, Nanoscale, 2011, 3, 1997 DOI: 10.1039/C0NR00950D

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