Enantioselective synthesis of spirooxoindoles via chiral auxiliary (bicyclic lactam) controlled SNAr reactions

Subhabrata Sen; Venkata R. Potti; Ramu Surakanti; Y. L. N. Murthy; Raghavaiah Pallepogu

doi:10.1039/C0OB00661K

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Enantioselective synthesis of spirooxoindoles via chiral auxiliary (bicyclic lactam) controlled S_NAr reactions†

Subhabrata Sen,*^a Venkata R. Potti,^ab Ramu Surakanti,^ab Y. L. N. Murthy^b and Raghavaiah Pallepogu^c

Author affiliations

* Corresponding authors

^a Medicinal Chemistry Department, GVK Biosciences, Plot 28A, IDA Nacharam, Hyderabad, India
E-mail: Subhabrata.sen@gvkbio.com
Fax: +91 40 2715 2999
Tel: +91 40 6628 1426

^b Department of Chemistry, Food, Drugs and Water, College of Science and Technology, Andhra University, Vishakhapatnam, India
E-mail: murthyyln@yahoo.co.in
Tel: +91 0891 2844 686

^c School of Chemistry, University of Hyderabad, Hyderabad, India

Abstract

A highly efficient enantioselective S_NAr reaction of chiral acyl bicyclic lactam with substituted-2,4-dinitrobenzenes was developed, affording products containing quarternary stereogenic centers. They are further utilized towards an enantioselective synthesis of spirooxoindoles.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/C0OB00661K
Article type: Communication
Submitted: 03 Sep 2010
Accepted: 13 Oct 2010
First published: 14 Oct 2010

Download Citation

Org. Biomol. Chem., 2011,9, 358-360

Permissions

Request permissions

Enantioselective synthesis of spirooxoindoles via chiral auxiliary (bicyclic lactam) controlled S_NAr reactions

S. Sen, V. R. Potti, R. Surakanti, Y. L. N. Murthy and R. Pallepogu, Org. Biomol. Chem., 2011, 9, 358 DOI: 10.1039/C0OB00661K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Organic & Biomolecular Chemistry