Issue 6, 2011
From the journal:

Organic & Biomolecular Chemistry

Highly enantioselective synthesis of syn-aldols of cyclohexanonesvia chiral primary amine catalyzed asymmetric transfer aldol reactions in ionic liquid†

Pengxin Zhou,a   Sanzhong Luo*b  and  Jin-Pei Cheng*ab  

* Corresponding authors

a Department of Chemistry and State Key Laboratory of Elemental-Organic Chemistry, Nankai University, Tianjin, China

b Beijing National Laboratory for Molecule Sciences (BNLMS), CAS Key Laboratory for Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
E-mail: luosz@iccas.ac.cn
Fax: +86-10-62554449
Tel: +86-10-62554446

Abstract

Chiral primary-tertiary diamine/TfOH was found to catalyze kinetic resolution of racemic syn-aldols of cyclohexanones in ionic liquid effectively, affording the chiral syn-aldols with up to 99 : 1 syn/anti and 99% ee.

Graphical abstract: Highly enantioselective synthesis of syn-aldols of cyclohexanonesvia chiral primary amine catalyzed asymmetric transfer aldol reactions in ionic liquid

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Article information

DOI
https://doi.org/10.1039/C0OB00682C
Article type
Paper
Submitted
06 Sep 2010
Accepted
23 Nov 2010
First published
24 Nov 2010

Org. Biomol. Chem., 2011,9, 1784-1790

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Highly enantioselective synthesis of syn-aldols of cyclohexanonesvia chiral primary amine catalyzed asymmetric transfer aldol reactions in ionic liquid

P. Zhou, S. Luo and J. Cheng, Org. Biomol. Chem., 2011, 9, 1784 DOI: 10.1039/C0OB00682C

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