Issue 4, 2011
From the journal:

Organic & Biomolecular Chemistry

Asymmetric organocatalytic Michael–α-amination sequence for the construction of a quaternary stereocenter†

Alaric Desmarchelier,a   Jérôme Marrot,a   Xavier Moreau*a  and  Christine Greck*a  

* Corresponding authors

a Institut Lavoisier de Versailles, UMR CNRS 8180, Université de Versailles-Saint-Quentin-en-Yvelines, 45, Avenue des Etats-Unis, Versailles Cedex, France
E-mail: moreau@chimie.uvsq.fr, greck@chimie.uvsq.fr

Abstract

Combination of secondary and primary amine-catalyzed organocascade Michael–α-amination is described. This sequence afforded α-hydrazino aldehydes bearing a quaternary stereocenter with high yield and excellent stereoselectivity.

Graphical abstract: Asymmetric organocatalytic Michael–α-amination sequence for the construction of a quaternary stereocenter

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Article information

DOI
https://doi.org/10.1039/C0OB00751J
Article type
Communication
Submitted
20 Sep 2010
Accepted
18 Nov 2010
First published
07 Dec 2010

Org. Biomol. Chem., 2011,9, 994-997

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Asymmetric organocatalytic Michael–α-amination sequence for the construction of a quaternary stereocenter

A. Desmarchelier, J. Marrot, X. Moreau and C. Greck, Org. Biomol. Chem., 2011, 9, 994 DOI: 10.1039/C0OB00751J

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