Issue 4, 2011
From the journal:

Organic & Biomolecular Chemistry

Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells†

Mingming Hu,a   Jiangli Fan,*a   Honglin Li,a   Kedong Song,b   Song Wang,a   Guanghui Chenga  and  Xiaojun Peng*a  

* Corresponding authors

a State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China
E-mail: pengxj@dlut.edu.cn, fanjl@dlut.edu.cn
Fax: +86-411-3989-3906
Tel: +86-411-3989-3899

b Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, China

Abstract

A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by 1H NMR, mass spectrometry analysis and Gaussian calculations.

Graphical abstract: Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

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Article information

DOI
https://doi.org/10.1039/C0OB00957A
Article type
Communication
Submitted
30 Oct 2010
Accepted
24 Nov 2010
First published
16 Dec 2010

Org. Biomol. Chem., 2011,9, 980-983

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Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

M. Hu, J. Fan, H. Li, K. Song, S. Wang, G. Cheng and X. Peng, Org. Biomol. Chem., 2011, 9, 980 DOI: 10.1039/C0OB00957A

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