Issue 5, 2011
From the journal:

Organic & Biomolecular Chemistry

A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates†

Riccardo Mossetti,a   Diego Caprioglio,a   Giampiero Colombano,a   Gian Cesare Trona  and  Tracey Pirali*a  

* Corresponding authors

a Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università degli Studi del Piemonte Orientale “A. Avogadro”, Via Bovio 6, Novara, Italy
E-mail: tracey.pirali@pharm.unipmn.it
Fax: +39 0321375853
Tel: +39 0321375821

Abstract

α-Isocyanoacetamides, acyl chlorides and dialkylacetylenedicarboxylates undergo a smooth multicomponent reaction to produce dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates in good yield. The scope and mechanism of this new multicomponent transformation are discussed.

Graphical abstract: A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates

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Article information

DOI
https://doi.org/10.1039/C0OB00979B
Article type
Paper
Submitted
03 Nov 2010
Accepted
14 Dec 2010
First published
15 Dec 2010

Org. Biomol. Chem., 2011,9, 1627-1631

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A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates

R. Mossetti, D. Caprioglio, G. Colombano, G. C. Tron and T. Pirali, Org. Biomol. Chem., 2011, 9, 1627 DOI: 10.1039/C0OB00979B

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