Issue 6, 2011

A rational approach to tuning the pKa values of rhodamines for living cell fluorescence imaging

Abstract

A novel strategy to systematically tune the pKa values of rhodamines is described. This strategy was applied to rationally develop compound 1e with a pKa of 6.5, the highest among rhodamine amide derivatives, and it could be employed to detect acidic pH variations in living cells with a turn-on signal.

Graphical abstract: A rational approach to tuning the pKa values of rhodamines for living cell fluorescence imaging

Supplementary files

Article information

Article type
Communication
Submitted
18 Nov 2010
Accepted
05 Jan 2011
First published
06 Jan 2011

Org. Biomol. Chem., 2011,9, 1723-1726

A rational approach to tuning the pKa values of rhodamines for living cell fluorescence imaging

L. Yuan, W. Lin and Y. Feng, Org. Biomol. Chem., 2011, 9, 1723 DOI: 10.1039/C0OB01045F

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