Issue 11, 2011
From the journal:

Organic & Biomolecular Chemistry

Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole†

Wen Chen,‡ab   Xiao-Dong Yang,‡a   Yan Li,c   Li-Juan Yang,b   Xue-Quan Wang,a   Gao-Lan Zhanga  and  Hong-Bin Zhang*a  

* Corresponding authors

a Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China
E-mail: zhanghb@ynu.edu.cnorzhanghbyd@gmail.com
Fax: +86-871-5035538
Tel: +86-871-5031119

b Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming, P. R. China

c State Key Laboratory for Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, P. R. China

Abstract

A series of novel hybrid compounds between dihydrobenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-1-position with an electron-donating dihydrobenzofuran, and the imidazolyl-3-position with a naphthylacyl or electron-rich phenacyl group, were vital for modulating cytotoxic activity.

Graphical abstract: Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole

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Article information

DOI
https://doi.org/10.1039/C1OB05116D
Article type
Paper
Submitted
21 Jan 2011
Accepted
25 Mar 2011
First published
25 Mar 2011

Org. Biomol. Chem., 2011,9, 4250-4255

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Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole

W. Chen, X. Yang, Y. Li, L. Yang, X. Wang, G. Zhang and H. Zhang, Org. Biomol. Chem., 2011, 9, 4250 DOI: 10.1039/C1OB05116D

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