Issue 11, 2011
From the journal:

Organic & Biomolecular Chemistry

Hybridization-sensitive fluorescence control in the near-infrared wavelength range

Shuji Ikeda,a   Hiroyuki Yanagisawa,a   Akiko Nakamura,a   Dan Ohtan Wang,a   Mizue Yukia  and  Akimitsu Okamoto*ab  

* Corresponding authors

a Advanced Science Institute, RIKEN, Wako, Saitama, Japan
E-mail: aki-okamoto@riken.jp
Fax: +81 48 467 9205
Tel: +81 48 467 9238

b PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama, Japan

Abstract

A series of near-infrared fluorescent probes were designed based on the concept of emission control caused by interdye excitonic interaction. The fluorescent probes showed very weak emission in the unhybridized state, whereas they emitted near-infrared fluorescence after hybridization with the complementary nucleic acid. The hybridization-dependent switching of fluorescence emission made it possible to monitor mRNA in human cells in the range of near-infrared wavelengths.

Graphical abstract: Hybridization-sensitive fluorescence control in the near-infrared wavelength range

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/C1OB05252G
Article type
Paper
Submitted
17 Feb 2011
Accepted
25 Mar 2011
First published
25 Mar 2011

Org. Biomol. Chem., 2011,9, 4199-4204

Permissions

Request permissions

Hybridization-sensitive fluorescence control in the near-infrared wavelength range

S. Ikeda, H. Yanagisawa, A. Nakamura, D. O. Wang, M. Yuki and A. Okamoto, Org. Biomol. Chem., 2011, 9, 4199 DOI: 10.1039/C1OB05252G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements