Rapid carbonylative coupling reactions using palladium(I) dimers: applications to 11CO-radiolabelling for the synthesis of PET tracers

Gabriella Buscemi; Philip W. Miller; Steven Kealey; Antony D. Gee; Nicholas J. Long; Jan Passchier; Ramon Vilar

doi:10.1039/C1OB05268C

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Rapid carbonylative coupling reactions using palladium(i) dimers: applications to ¹¹CO-radiolabelling for the synthesis of PET tracers†

Gabriella Buscemi,^a Philip W. Miller,^a Steven Kealey,^bc Antony D. Gee,^ad Nicholas J. Long,^a Jan Passchier^b and Ramon Vilar*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Imperial College London, South Kensington, London, UK
E-mail: r.vilar@imperial.ac.uk
Fax: +44 2075 941139
Tel: +44 2075941967

^b GlaxoSmithKline, Clinical Imaging Centre, Imperial College, Hammersmith Hospital, London, UK

^c Department of Pharmacy and Pharmacology, University of Bath, Bath, UK

^d Division of Imaging Sciences and Biomedical Engineering, King's College London, St Thomas' Hospital, London, UK

Abstract

Palladium dimers with sterically hindered phosphines have been shown to be excellent pre-catalysts for the aminocarbonylation of aryl halides to yield amides and one of them has been successfully employed as a pre-catalyst for the synthesis of ¹¹C-radiolabelled amides for PET imaging.

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Article information

DOI: https://doi.org/10.1039/C1OB05268C
Article type: Paper
Submitted: 14 Jan 2011
Accepted: 24 Feb 2011
First published: 25 Feb 2011

Download Citation

Org. Biomol. Chem., 2011,9, 3499-3503

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Rapid carbonylative coupling reactions using palladium(I) dimers: applications to ¹¹CO-radiolabelling for the synthesis of PET tracers

G. Buscemi, P. W. Miller, S. Kealey, A. D. Gee, N. J. Long, J. Passchier and R. Vilar, Org. Biomol. Chem., 2011, 9, 3499 DOI: 10.1039/C1OB05268C

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Organic & Biomolecular Chemistry