Issue 11, 2011
From the journal:

Organic & Biomolecular Chemistry

Efficient synthesis of esermethole and its analogues†

Yongyun Zhou,a   Yuanhong Zhao,a   Xiaoyong Dai,a   Jianping Liu,a   Liang Lia  and  Hongbin Zhang*a  

* Corresponding authors

a Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan, P. R. China
E-mail: zhanghb@ynu.edu.cnorzhang_hongbin@hotmail.com
Fax: 86-871-5035538

Abstract

In this work, a general and flexible synthetic route towards the synthesis of pyrroloindoline alkaloids was developed. This new strategy features with a palladium mediated sequential arylation–allylation of o-bromoanilides and leads to the construction of oxindoles bearing a full carbon quaternary center. The cheap triphenylphosphine was proved to be a highly effective ligand for this one pot transformation. On the basis of this new method, esermethole and its analogues were synthesized.

Graphical abstract: Efficient synthesis of esermethole and its analogues

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1OB05275F
Article type
Paper
Submitted
20 Feb 2011
Accepted
10 Mar 2011
First published
07 Apr 2011

Org. Biomol. Chem., 2011,9, 4091-4097

Permissions

Request permissions

Efficient synthesis of esermethole and its analogues

Y. Zhou, Y. Zhao, X. Dai, J. Liu, L. Li and H. Zhang, Org. Biomol. Chem., 2011, 9, 4091 DOI: 10.1039/C1OB05275F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements