Issue 15, 2011

A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

Abstract

A practical synthesis of the Rho-Kinase inhibitor Y-27632 and two new fluoro derivatives was achieved in seven steps and with a good overall yield of 45% starting from commercially available (R)-1-phenylethylamine. Compared to Y-27632 the new fluoro derivatives showed reduced or no effect on hPSC vitality and expansion after dissociation in human pluripotent stem cells.

Graphical abstract: A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

Supplementary files

Article information

Article type
Paper
Submitted
02 Mar 2011
Accepted
26 Apr 2011
First published
27 Apr 2011

Org. Biomol. Chem., 2011,9, 5503-5510

A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

J. Paleček, R. Zweigerdt, R. Olmer, U. Martin, A. Kirschning and G. Dräger, Org. Biomol. Chem., 2011, 9, 5503 DOI: 10.1039/C1OB05332A

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