Issue 15, 2011

Trp-Trp pairs as β-hairpin stabilisers: Hydrogen-bonded versus non-hydrogen-bonded sites

Abstract

Trp–Trp pairs have emerged as a successful strategy for β-hairpin stabilization. Using loop 3 of Vammin as a template, we experimentally demonstrate that the contribution of Trp–Trp pairs to β-hairpin stability depends on β-sheet periodicity, that is, they are stabilising at non-hydrogen-bonded sites, but not at hydrogen-bonded positions.

Graphical abstract: Trp-Trp pairs as β-hairpin stabilisers: Hydrogen-bonded versus non-hydrogen-bonded sites

Supplementary files

Article information

Article type
Paper
Submitted
07 Mar 2011
Accepted
05 May 2011
First published
05 May 2011

Org. Biomol. Chem., 2011,9, 5487-5492

Trp-Trp pairs as β-hairpin stabilisers: Hydrogen-bonded versus non-hydrogen-bonded sites

C. M. Santiveri, M. J. Pérez de Vega, R. González-Muñiz and M. A. Jiménez, Org. Biomol. Chem., 2011, 9, 5487 DOI: 10.1039/C1OB05353A

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