Issue 15, 2011
From the journal:

Organic & Biomolecular Chemistry

Copper-catalyzed direct thiolation of azoles with aliphatic thiols†

An-Xi Zhou,a   Xue-Yuan Liu,*a   Ke Yang,a   Shu-Chun Zhaoa  and  Yong-Min Lianga  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China
E-mail: liuxuey@lzu.edu.cn

Abstract

Cu(II)-catalyzed direct thiolation of azoles with thiols is described via intermolecular C–S bond formation/C–H functionalization under oxidative conditions. Both aryl thiols and aliphatic thiols are used as coupling partners, and furnished the thiolation products in moderate to good yields. The reaction is compatible with a wide range of heterocycles including oxazole, thiazole, imidazole and oxadiazole.

Graphical abstract: Copper-catalyzed direct thiolation of azoles with aliphatic thiols

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Article information

DOI
https://doi.org/10.1039/C1OB05395G
Article type
Paper
Submitted
14 Mar 2011
Accepted
21 Apr 2011
First published
26 Apr 2011

Org. Biomol. Chem., 2011,9, 5456-5462

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Copper-catalyzed direct thiolation of azoles with aliphatic thiols

A. Zhou, X. Liu, K. Yang, S. Zhao and Y. Liang, Org. Biomol. Chem., 2011, 9, 5456 DOI: 10.1039/C1OB05395G

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