Issue 19, 2011

N-Heterocyclic carbene-catalyzed aza-Michael addition

Abstract

Aza-Michael addition of amines, including aromatic and aliphatic amines, with α, β-unsaturated ketones was realized employing N-Heterocyclic Carbene (NHC) as organocatalyst, yielding β-amino ketones with up to 98% yield.

Graphical abstract: N-Heterocyclic carbene-catalyzed aza-Michael addition

Supplementary files

Article information

Article type
Paper
Submitted
18 Mar 2011
Accepted
23 Jun 2011
First published
23 Jun 2011

Org. Biomol. Chem., 2011,9, 6715-6720

N-Heterocyclic carbene-catalyzed aza-Michael addition

Q. Kang and Y. Zhang, Org. Biomol. Chem., 2011, 9, 6715 DOI: 10.1039/C1OB05429E

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