Issue 21, 2011

Click-chemistry approach to isoxazole-containing α-CF3-substituted α-aminocarboxylates and α-aminophosphonates

Abstract

A convenient strategy for the synthesis of isoxazole-containing α-CF3-substituted α-aminocarboxylates and α-aminophosphonates have been developed. The method is based on copper-catalyzed 1,3-dipolar cycloaddition of different aromatic nitrile oxides to functionalized acetylenes.

Graphical abstract: Click-chemistry approach to isoxazole-containing α-CF3-substituted α-aminocarboxylates and α-aminophosphonates

Article information

Article type
Paper
Submitted
28 Jun 2011
Accepted
29 Jul 2011
First published
01 Aug 2011

Org. Biomol. Chem., 2011,9, 7335-7342

Click-chemistry approach to isoxazole-containing α-CF3-substituted α-aminocarboxylates and α-aminophosphonates

D. V. Vorobyeva, N. M. Karimova, I. L. Odinets, G. Röschenthaler and S. N. Osipov, Org. Biomol. Chem., 2011, 9, 7335 DOI: 10.1039/C1OB06040F

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