Issue 21, 2011
From the journal:

Organic & Biomolecular Chemistry

Exploring isonitrile-based click chemistry for ligation with biomolecules†

Henning Stöckmann,ab   André A. Neves,b   Shaun Stairs,a   Kevin M. Brindleb  and  Finian J. Leeper*a  

* Corresponding authors

a University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, UK
E-mail: fjl1@cam.ac.uk
Fax: +44 (0) 1223 336 362
Tel: +44 (0) 1223 336 403

b Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, UK

Abstract

We show here that isonitriles can perform click reactions with tetrazines in aqueous media, making them promising candidates for ligation reactions in chemical biology and polymer chemistry. This is the first time that a [4+1] cycloaddition has been used as a biocompatible ligation reaction.

Graphical abstract: Exploring isonitrile-based click chemistry for ligation with biomolecules

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Article information

DOI
https://doi.org/10.1039/C1OB06424J
Article type
Communication
Submitted
19 Aug 2011
Accepted
24 Aug 2011
First published
25 Aug 2011

Org. Biomol. Chem., 2011,9, 7303-7305

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Exploring isonitrile-based click chemistry for ligation with biomolecules

H. Stöckmann, A. A. Neves, S. Stairs, K. M. Brindle and F. J. Leeper, Org. Biomol. Chem., 2011, 9, 7303 DOI: 10.1039/C1OB06424J

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