Issue 2, 2011
From the journal:

Chemical Science

Palladium-catalyzed amination reactions in flow: overcoming the challenges of clogging via acoustic irradiation†

Timothy Noël,a   John R. Naber,a   Ryan L. Hartman,b   Jonathan P. McMullen,b   Klavs F. Jensen*b  and  Stephen L. Buchwald*a  

* Corresponding authors

a Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts, USA
E-mail: sbuchwal@mit.edu.
Fax: +1-617-253-3297
Tel: +1-617-253-1885

b Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts, USA
E-mail: kfjensen@mit.edu.
Fax: +1 617 298 8992
Tel: +1 617 253 4589

Abstract

A continuous-flow palladium-catalyzed amination reaction was made possible through efficient handling of solids via acoustic irradiation. Various diarylamines were obtained with reaction times ranging from 20 s to 10 min.

Graphical abstract: Palladium-catalyzed amination reactions in flow: overcoming the challenges of clogging via acoustic irradiation

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Article information

DOI
https://doi.org/10.1039/C0SC00524J
Article type
Edge Article
Submitted
16 Oct 2010
Accepted
18 Nov 2010
First published
03 Dec 2010

Chem. Sci., 2011,2, 287-290

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Palladium-catalyzed amination reactions in flow: overcoming the challenges of clogging via acoustic irradiation

T. Noël, J. R. Naber, R. L. Hartman, J. P. McMullen, K. F. Jensen and S. L. Buchwald, Chem. Sci., 2011, 2, 287 DOI: 10.1039/C0SC00524J

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